By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

largely revised and up-to-date, Antisense Drug expertise: rules, concepts, and purposes, moment Edition displays the logarithmic development made some time past 4 years of oligonucleotide-based cures, and, specifically, antisense therapeutics and study. studying classes realized from the scientific trials of first new release medicinal drugs, the e-book evaluates the expertise as a complete and gives new instructions and avenues of analysis and improvement.

Divided into 5 elements, the booklet starts off with a radical advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the aptitude therapeutics of splice switching oligonucleotides. best researchers exhibit the fundamentals of oligonucleotide therapeutics partially by means of delineating medicinal chemistry, pharmacokinetics, and supply routes resembling liposomal formulations for nucleic acid delivery.  half 3 info hybridization dependent medicinal drugs and considers the dramatic advances represented through 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical periods of substances and mechanisms of motion are defined partially 4 with additional discussions on enhancing the second one iteration antisense medicinal drugs. the ultimate half delves deeply into healing purposes. Contributing authors study the potential for antisense medications for the relief of cardiovascular ailments, metabolic illnesses, inflammatory illnesses, melanoma, neurological problems, and immune modulation.

Presenting a hugely distinct, lucid dialogue of the extraordinary advances within the box, Antisense Drug know-how: ideas, options, and purposes, moment Edition presents the platform for researchers to proceed to aggressively pursue the nice chance represented by way of this intriguing technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke


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